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The goal of the GRACE initiative is to enhance the quality of observational comparative effectiveness research (CER), and to facilitate its use for decision-making about therapeutic alternatives.

GRACE Principles

Grace Principles PDF

Designed as a set of high-level questions, the GRACE Principles layout the elements of good practice for the design, conduct, analysis, and reporting of observational CER studies.

The GRACE principles are endorsed by the International Society for Pharmacoepidemiology and supported by a number of professionals and organizations. See also:

GRACE Principles: Recognizing High-Quality Observational Studies of Comparative Effectiveness

Dreyer NA, Schneeweiss S, McNeil BJ, et al. Am J Manag Care. 2010:16(6):467-471

GRACE Checklist

Grace Checklist PDF

The GRACE Checklist is designed to guide the assessment of observational studies of comparative effectiveness in terms of their quality and usefulness for decision-making.

Developed from review of published literature and tested by hundreds of volunteers from around the world, the GRACE Checklist provides a validated tool for screening the quality of observational comparative effectiveness studies.

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