Good ReseArch for Comparative Effectiveness

The Grace principles will address good practice for the design, conduct, analysis, and reporting of observational studies of comparative effectiveness. The principles are intended to meet the needs of both those who conduct such studies and those who need to evaluate the rigor of such studies to inform decision-making regarding therapeutic alternatives.

The ultimate goal of the principles is to enhance the quality of observational comparative effectiveness research and thus promote and facilitate the use of this research to support decision-making by patients, physicians, and payers. The draft principles will focus on studies of pharmaceutical products, but are intended to be applicable more broadly.

The GRACE initiative is actively seeking collaborators from government, academia, health plans, professional organizations, and other interested parties to participate in developing the principles and reviewing the draft. We are also interested in gathering case studies of observational comparative effectiveness studies that have been used to support decision-making.

If you are interested in participating or contributing a case study, please email us.